Combination Salbutamol (Albuterol)
Mechanism of Action
Selectively stimulates beta-2 adrenergic receptors in bronchial smooth muscle, causing bronchodilation.
Indications
Combination formulation. Acute bronchospasm, asthma, COPD exacerbation, exercise-induced bronchospasm. Also useful for regolith dust bronchospasm in exposed workers.
Dosing
Standard (Earth)
See Combination prescribing information. Inhaler: 1-2 puffs (100-200 mcg) every 4-6h. Nebulization: 2.5-5 mg in 3 mL NS every 4-8h.
Lunar Protocol
Metered-dose inhaler function in 1/6g requires special consideration — propellant delivery may be altered. Nebulizer is preferred in lunar medical bay context. Inhaler spacer device recommended for all residents. Regolith-exposed workers: prophylactic use before decontamination shower in severe exposure.
Storage
Standard
Room temperature, protect from heat and direct sunlight.
Lunar (Radiation + Temperature)
Store at 15-25°C. Pressurized MDI canister sensitive to temperature extremes — avoid near habitat wall (temperature variation) or near heating elements. Radiation shielding. 24-month supply. Nebulizer solution more stable than MDI in lunar storage conditions.
Supply Chain & Lunar Pharmacy Notes
WHO Essential Medicine. Very high consumption expected in regolith-exposed workforce. Stock both MDI and nebulizer solution forms. Nebulizer machine requires maintenance — include in medical equipment maintenance schedule.
Drug Interactions
Beta-blockers (antagonism). Diuretics (hypokalemia risk). MAOIs and tricyclics (cardiovascular effects).
Contraindications
Known hypersensitivity. Use with caution in severe cardiac disease.
Side Effects
Tremor, tachycardia, hypokalemia, headache.
Lunar Alternatives
Ipratropium (anticholinergic, good combination with salbutamol), terbutaline (alternative SABA).