Topical Epinephrine (Adrenaline)
Mechanism of Action
Stimulates alpha-1 (vasoconstriction), beta-1 (cardiac stimulation), and beta-2 (bronchodilation) adrenergic receptors.
Indications
Topical formulation. Anaphylaxis (life-saving), cardiac arrest (ACLS protocol), severe bronchospasm.
Dosing
Standard (Earth)
See Topical prescribing information. Anaphylaxis: 0.3-0.5 mg IM (anterolateral thigh). Cardiac arrest: 1 mg IV every 3-5 minutes.
Lunar Protocol
IM injection in 1/6g: anterolateral thigh or deltoid both effective. Absorption rate may differ from Earth due to altered muscle perfusion — monitor response carefully. In cardiac arrest, CPR technique in 1/6g requires modification (body strapping for compressions). Dose unchanged — cardiac physiology is unchanged.
Storage
Standard
Room temperature, protect from light.
Lunar (Radiation + Temperature)
CRITICAL STOCK. Multiple pre-filled syringes in crash kit plus EpiPen auto-injectors for first responders. Protect from temperature extremes and light (degradation to inactive adrenochrome occurs with heat/light). Radiation shielded. Replace every 12-18 months — stability critical. Check solution color: pink = degraded, replace immediately.
Supply Chain & Lunar Pharmacy Notes
Absolutely essential. Non-negotiable stock item. All habitats and EVA first-aid kits must contain epinephrine. Anaphylaxis to food, stings, or medications in a lunar habitat without epinephrine is a preventable death.
Drug Interactions
Beta-blockers (may antagonize), tricyclics (enhanced cardiovascular effects), MAOIs.
Contraindications
No absolute contraindications in anaphylaxis or cardiac arrest. Relative: hyperthyroidism, severe hypertension, cardiac arrhythmia.
Side Effects
Tachycardia, hypertension, anxiety, tremor, arrhythmia.
Lunar Alternatives
No equivalent for anaphylaxis. Vasopressin alternative in cardiac arrest.