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Longitudinal Study of Bone Mineral Density in Lunar Residents: A 24-Month Follow-Up: Expert Consensus

Dr. P. Kowalski · Lunar Medical Research Cooperative
Journal of Lunar Medicine · Vol. 5, No. 4 · September 29, 2023

Abstract

Follow-up investigation building on prior work. We present longitudinal DXA data from 47 lunar residents over 24 months, comparing bone mineral density changes in residents following standard exercise protocol versus augmented bisphosphonate therapy. Residents on standard protocol alone showed 8.2% femoral neck BMD loss at 12 months. The bisphosp...

Extended analysis and updated findings. Introduction

The preservation of bone mineral density (BMD) represents one of the most critical challenges in long-duration lunar habitation. Prior studies from orbital spaceflight have documented BMD losses of 1-2% per month in weight-bearing bones without countermeasures — losses that, if extrapolated to multi-year lunar missions, pose a substantial fragility fracture risk.

The lunar environment offers a partial mitigation compared to zero-gravity spaceflight: 1/6 Earth gravity still provides some mechanical loading stimulus to bone. However, early data from the first generation of lunar residents suggests BMD loss rates of 0.4-0.8% per month, still well above any natural rate of bone loss in ambulatory adults.

Methods

Forty-seven adult residents of three lunar habitats were enrolled...

Keywords

bone mineral density, osteoporosis, bisphosphonate, lunar, DXA, femoral neck